Article
PON1Q192R genetic polymorphism modifies organophosphorous pesticide effects on semen quality and DNA integrity in agricultural workers from southern Mexico.
Toxicology and applied pharmacology - 15 Jul 2008
Pérez-Herrera N, Polanco-Minaya H, Salazar-Arredondo E, Solís-Heredia M J, Hernández-Ochoa I, Rojas-García E, Alvarado-Mejía J, Borja-Aburto V H, Quintanilla-Vega B
Abstract excerpt
Pesticide exposure, including organophosphorous (OP) insecticides, has been associated with poor semen quality, and paraoxonase (PON1), an enzyme involved in OP deactivation, may have a role on their susceptibility, due to PON1 polymorphisms. Our objective was to evaluate the role of PON1Q192R polymorphism on the susceptibility to OP toxicity on semen quality and DNA integrity in agricultural workers. A...
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