Article
Morphology antibody chromosome technique for determining phenotype and genotype of the same cell.
Current protocols in human genetics - 1 Feb 2005
Knuutila Sakari
Abstract excerpt
The morphology antibody chromosome (MAC) technique is a powerful combination of methods that permits analysis of both phenotype and genotype on a single interphase or mitotic cell as a basis for lineage analysis of neoplastic and normal cells. This unit describes MAC with sequential phenotypic analysis using antibody and an alkaline phosphatase anti-alkaline phosphatase (APAAP) complex and genotypic analysis...
Topics
- Chromosome Banding
- Chromosomes, Human
- Genotype
- Humans
- In Situ Hybridization
- Phenotype
