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Article

Mechanisms of retinal ganglion specific-cell death in Leber hereditary optic neuropathy.

Transactions of the American Ophthalmological Society - 1 Jan 2007

Levin Leonard A

Abstract excerpt

PURPOSE: Leber hereditary optic neuropathy (LHON) results from point mutations in mitochondrial DNA (mtDNA) present in all cells but is only manifested in retinal ganglion cells (RGCs). Given that RGCs use superoxide for intracellular signaling after axotomy, and that LHON mutations increase superoxide levels in non-RGC transmitochondrial cybrids, I hypothesized that RGCs regulate superoxide levels differently...

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Identifiers

PMID: 18427623
PMCID: PMC2258117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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