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Article

Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.

Progress in retinal and eye research - 1 Mar 2011

Yu-Wai-Man Patrick, Griffiths Philip G, Chinnery Patrick F

Abstract excerpt

Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are the two most common inherited optic neuropathies in the general population. Both disorders share striking pathological similarities, marked by the selective loss of retinal ganglion cells (RGCs) and the early involvement of the papillomacular bundle. Three mitochondrial DNA (mtDNA) point mutations; m.3460G>A, m.11778G>A, and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21112411
DOI: 10.1016/j.preteyeres.2010.11.002
PMCID: PMC3081075

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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