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Article

Involvement of endoplasmic reticulum stress in rotenone-induced leber hereditary optic neuropathy model and the discovery of new therapeutic agents.

Journal of pharmacological sciences - 1 Oct 2021

Aoyama Yakumo, Inagaki Satoshi, Aoshima Kota, Iwata Yuki, Nakamura Shinsuke, Hara Hideaki, Shimazawa Masamitsu

Abstract excerpt

Leber hereditary optic neuropathy (LHON) is caused by mitochondrial DNA mutations and is the most common inherited mitochondrial disease. It is responsible for central vision loss in young adulthood. However, the precise mechanisms of onset are unknown. This study aimed to elucidate the mechanisms underlying LHON pathology and to discover new therapeutic agents. First, we assessed whether rotenone, a...

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Source

Identifiers

PMID: 34384568
DOI: 10.1016/j.jphs.2021.07.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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