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Article

Molecular Mechanisms That Differentiate Apoptosis from Programmed Necrosis

6 Dec 2012

Abstract excerpt

Programmed cell death is physiological when disposing of senescent, dysfunctional, or redundant cells, but pathological if these cells cannot be replaced. Mitochondria help determine cell fate as "gatekeepers" of apoptosis and effectors of cell necrosis. Apoptosis was first described 40 years ago this year. Cell suicide (or the less emotionally charged "programmed cell death") impacts organism development, normal...

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PMID: 23222994
DOI: 10.1177/0192623312466961

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