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Article

Maldi-TOF mass spectrometry for trisomy detection.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008

Huang Dorothy J, Nelson Matthew R, Holzgreve Wolfgang

Abstract excerpt

Matrix-associated laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is a tool currently under investigation for use in prenatal detection of abnormalities in chromosome number, such as trisomy 21. Because of its ability to detect extremely small differences in mass, even to the level of a single nucleotide difference, this method can be applied to the detection of single-nucleotide...

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Source

Identifiers

PMID: 18425476
DOI: 10.1007/978-1-59745-066-9_9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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