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Article

Gene Expression Analysis in gla-Mutant Zebrafish Reveals Enhanced Ca2+ Signaling Similar to Fabry Disease.

International journal of molecular sciences - 26 Dec 2022

Elsaid Hassan Osman Alhassan, Tjeldnes Håkon, Rivedal Mariell, Serre Camille, Eikrem Øystein, Svarstad Einar, Tøndel Camilla, Marti Hans-Peter, Furriol Jessica, Babickova Janka

Abstract excerpt

Fabry disease (FD) is an X-linked inborn metabolic disorder due to partial or complete lysosomal α-galactosidase A deficiency. FD is characterized by progressive renal insufficiency and cardio- and cerebrovascular involvement. Restricted access on Gb3-independent tissue injury experimental models has limited the understanding of FD pathophysiology and delayed the development of new therapies. Accumulating...

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PMID: 36613802
DOI: 10.3390/ijms24010358
PMCID: PMC9820748

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