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Article

Regardless of genotype, offspring of VIP-deficient female mice exhibit developmental delays and deficits in social behavior.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience - 1 Aug 2008

Lim Maria A, Stack Conor M, Cuasay Katrina, Stone Madeleine M, McFarlane Hewlet G, Waschek James A, Hill Joanna M

Abstract excerpt

Pharmacological studies indicate that vasoactive intestinal peptide (VIP) may be necessary for normal embryonic development in the mouse. For example, VIP antagonist treatment before embryonic day 11 resulted in developmental delays, growth restriction, modified adult brain chemistry and reduced social behavior. Here, developmental milestones, growth, and social behaviors of neonates of VIP-deficient mothers (VIP...

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Identifiers

PMID: 18423945
DOI: 10.1016/j.ijdevneu.2008.03.002
PMCID: PMC2494581

Genes

VIP

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