Article
Lack of association between LOXL1 variants and primary open-angle glaucoma in three different populations.
Investigative ophthalmology & visual science - 1 Aug 2008
Liu Yutao, Schmidt Silke, Qin Xuejun, Gibson Jason, Hutchins Kristen, Santiago-Turla Cecile, Wiggs Janey L, Budenz Donald L, Akafo Stephen, Challa Pratap, Herndon Leon W, Hauser Michael A, Allingham R Rand
Abstract excerpt
PURPOSE: Significant association has recently been reported between pseudoexfoliation glaucoma (XFG) and two single-nucleotide polymorphisms (SNPs), rs3825942, and rs1048661, in the lysyl oxidase-like 1 gene (LOXL1). The purpose of this study was to investigate whether XFG-associated variants of LOXL1 play a significant role in primary open-angle glaucoma in the Caucasian, African-American, and Ghanaian...
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