Article
Major LOXL1 risk allele is reversed in exfoliation glaucoma in a black South African population.
Molecular vision - 21 Apr 2010
Williams Susan E I, Whigham Benjamin T, Liu Yutao, Carmichael Trevor R, Qin Xuejun, Schmidt Silke, Ramsay Michele, Hauser Michael A, Allingham R Rand
Abstract excerpt
PURPOSE: To investigate whether variants in the lysyl oxidase-like 1 (LOXL1) gene are associated with exfoliation glaucoma (XFG) and primary open-angle glaucoma (POAG) in an ancestral population from South Africa. METHODS: Black South African subjects with XFG, POAG, and age matched unaffected controls were recruited from the St. John Eye Hospital in Soweto, Johannesburg, South Africa, using standard clinical...
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