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Article

A digenic combination of polymorphisms within ESR1 and ESR2 genes are associated with age at menarche in the Spanish population.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2008

Mendoza Nicolás, Morón Francisco Jesús, Quereda Francisco, Vázquez Francisco, Rivero Mari C, Martínez-Astorquiza Txantón, Real Luis M, Sánchez-Borrego Rafael, González-Pérez Antonio, Ruiz Agustín

Abstract excerpt

In the present study, the authors look at an association of genetic variants within estrogen synthesis and signaling pathways and age at menarche (AAM) in Spanish women. They analyzed 9 polymorphisms in 6 different genes in 714 well-characterized postmenopausal women from Spain. They performed a quantitative trait locus study of these markers individually or in digenic combinations in relation to AAM. None of the...

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Source

Identifiers

PMID: 18421025
DOI: 10.1177/1933719107314064

Genes

ESR1
ESR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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