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Article

Genetic polymorphisms of ESR1 and ESR2 that may influence estrogen activity and the risk of hypospadias.

Human reproduction (Oxford, England) - 1 Jun 2008

Ban Susumu, Sata Fumihiro, Kurahashi Norie, Kasai Setsuko, Moriya Kimihiko, Kakizaki Hidehiro, Nonomura Katsuya, Kishi Reiko

Abstract excerpt

BACKGROUND: The etiology of hypospadias is regarded as a complex disorder with both genetic and environmental contributions. Although alterations in androgen activity have been associated with hypospadias, few associations with estrogen activity have been documented. Here, we assessed genetic polymorphisms in estrogen receptor genes and their association with hypospadias. METHODS: Using a case-control study of 59...

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Source

Identifiers

PMID: 18375409
DOI: 10.1093/humrep/den098

Genes

ESR1
ESR2

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