Article
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development.
Developmental biology - 15 Jul 2007
Ramasamy Suresh K, Mailleux Arnaud A, Gupte Varsha V, Mata Francisca, Sala Frédéric G, Veltmaat Jacqueline M, Del Moral Pierre M, De Langhe Stijn, Parsa Sara, Kelly Lisa K, Kelly Robert, Shia Wei, Keshet Eli, Minoo Parviz, Warburton David, Bellusci Savério
Abstract excerpt
The key role played by Fgf10 during early lung development is clearly illustrated in Fgf10 knockout mice, which exhibit lung agenesis. However, Fgf10 is continuously expressed throughout lung development suggesting extended as well as additional roles for FGF10 at later stages of lung organogenesis. We previously reported that the enhancer trap Mlcv1v-nLacZ-24 transgenic mouse strain functions as a reporter for...
Topics
- Animals
- Animals, Newborn
- Embryonic Stem Cells
- Epithelial Cells
- Female
- Fibroblast Growth Factor 10
- Gene Dosage
- Gene Expression Regulation, Developmental
- Heterozygote