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Article

Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

Mycologia - 1 Jan 2000

Bills Gerald F, Platas Gonzalo, Overy David P, Collado Javier, Fillola Asunción, Jiménez María Rosa, Martín Jesús, del Val Antonio González, Vicente Francisca, Tormo J Rubén, Peláez Fernando, Calati Kathleen, Harris Guy, Parish Craig, Xu Deming, Roemer Terry

Abstract excerpt

Evaluation of fungal fermentation extracts with whole cell Candida albicans activity resulted in the identification of a novel class of isoxazolidinone-containing metabolites named parnafungins. Chemical-genetic profiling with the C. albicans fitness test identified the biochemical target as inhi...

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PMID: 19623926
DOI: 10.3852/08-163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19623926-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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