Article
Effect of circadian clock mutations on DNA damage response in mammalian cells.
Cell cycle (Georgetown, Tex.) - 15 Sept 2012
Gaddameedhi Shobhan, Reardon Joyce T, Ye Rui, Ozturk Nuri, Sancar Aziz
Abstract excerpt
The circadian clock is a global regulatory mechanism that confers daily rhythmicity on many biochemical and physiological functions, including DNA excision repair in mammalian organisms. Here, we investigated the effect of the circadian clock on the major DNA damage response pathways by using mou...
Topics
- Animals
- Apoptosis
- Ataxia Telangiectasia Mutated Proteins
- CLOCK Proteins
- Cell Cycle Checkpoints
- Cell Cycle Proteins
- Cell Line
- Cell Survival
- Checkpoint Kinase 2
- Circadian Clocks
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Down-Regulation
- Enzyme Activation
- Feedback, Physiological
- Humans
- Mammals