Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of circadian clock mutations on DNA damage response in mammalian cells.

Cell cycle (Georgetown, Tex.) - 15 Sept 2012

Gaddameedhi Shobhan, Reardon Joyce T, Ye Rui, Ozturk Nuri, Sancar Aziz

Abstract excerpt

The circadian clock is a global regulatory mechanism that confers daily rhythmicity on many biochemical and physiological functions, including DNA excision repair in mammalian organisms. Here, we investigated the effect of the circadian clock on the major DNA damage response pathways by using mouse cell lines mutated in genes encoding proteins in the positive (Bmal1, CLOCK) or negative (Cry 1/2, Per 1/2) arms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Cycle Proteins
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Survival

Share to DNA-Binding Proteins

Share to DNA Damage

Share to DNA Repair

Share to Enzyme Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 22918252
DOI: 10.4161/cc.21771
PMCID: PMC3466558

Genes

CLOCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of circadian clock mutations on DNA damage response in mammalian cells.PMID 22918252Read ↗

Circadian clock control of the cellular response to DNA damage.Semantic proximity Read ↗

Circadian clock, carcinogenesis, chronochemotherapy connectionsSemantic proximity Read ↗

Mutations of the circadian clock genes Cry, Per, or Bmal1 have different effects on the transcribed and nontranscribed strands of cycling genes.Semantic proximity Read ↗

Disruption of the circadian clock due to the Clock mutation has discrete effects on aging and carcinogenesis.Semantic proximity Read ↗

Circadian tempo: a paradigm for genome stability?Semantic proximity Read ↗

Cryptochrome, Circadian Cycle, Cell Cycle Checkpoints, and CancerSemantic proximity Read ↗

The circadian clock protects against ionizing radiation-induced cardiotoxicity.Semantic proximity Read ↗

Circadian effects on UV-induced damage and mutations.Semantic proximity Read ↗

Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene.Semantic proximity Read ↗

Casein kinase 2, circadian clocks, and the flight from mutagenic light.Semantic proximity Read ↗

The circadian clock: from molecules to behaviour.Semantic proximity Read ↗

A clock shock: mouse CLOCK is not required for circadian oscillator function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.