Article
Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics.
Neurobiology of disease - 1 Jun 2008
Burnett Barrington G, Andrews Jaime, Ranganathan Srikanth, Fischbeck Kenneth H, Di Prospero Nicholas A
Abstract excerpt
Huntington's disease is caused by polyglutamine expansion in the huntingtin protein. Huntingtin directly interacts with profilin, a major actin monomer sequestering protein and a key integrator of signals leading to actin polymerization. We observed a progressive loss of profilin in the cerebral cortex of Huntington's disease patients, and in cell culture and Drosophila models of polyglutamine disease. This loss...
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