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Article

Profilin Directly Promotes Microtubule Growth through Residues Mutated in Amyotrophic Lateral Sclerosis.

Current biology : CB - 20 Nov 2017

Henty-Ridilla Jessica L, Juanes M Angeles, Goode Bruce L

Abstract excerpt

Profilin is an abundant actin monomer-binding protein with critical actin regulatory roles in vivo [1, 2]. However, profilin also influences microtubule dynamics in cells, which may be mediated in part through its interactions with formins that in turn bind microtubules [3, 4]. Specific residues on human profilin-1 (PFN1) are mutated in patients with amyotrophic lateral sclerosis (ALS) [5, 6]. However, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29129529
DOI: 10.1016/j.cub.2017.10.002
PMCID: PMC5772683

Genes

PFN1

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