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Article

Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.

Cancer research - 15 Apr 2008

Zhu Quan-Sheng, Ren Wenhong, Korchin Borys, Lahat Guy, Dicker Adam, Lu Yiling, Mills Gordon, Pollock Raphael E, Lev Dina

Abstract excerpt

The AKT signaling pathway is activated in soft tissue sarcoma (STS). However, AKT blockade has not yet been studied as a potential targeted therapeutic approach. Here, we examined the in vitro and in vivo effects of AKT inhibition in STS cells. Western blot analysis was used to evaluate the expression of AKT pathway components and the effect of AKT stimulation and inhibition on their phosphorylation. Cell culture...

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Source

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Identifiers

PMID: 18413758
DOI: 10.1158/0008-5472.CAN-07-6268
PMCID: PMC4174465

Genes

STS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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