Article
Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia.
European heart journal - 1 Jun 2008
van der Net Jeroen B, van Etten Jeroen, Yazdanpanah Mojgan, Dallinga-Thie Geesje M, Kastelein John J P, Defesche Joep C, Koopmans Richard P, Steyerberg Ewout W, Sijbrands Eric J G
Abstract excerpt
AIMS: Familial hypercholesterolaemia (FH) is characterized by premature coronary heart disease (CHD). However, the incidence of CHD varies considerably among FH patients. Genetic variation in the renin-angiotensin-aldosterone system (RAAS) and the adrenalin/noradrenalin system may be of importance in determining the CHD risk in FH, because of their involvement in CHD. We investigated the association between CHD...
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