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Article

Multiple roles of Notch signaling in the regulation of epidermal development.

Developmental cell - 1 Apr 2008

Moriyama Mariko, Durham André-Dante, Moriyama Hiroyuki, Hasegawa Kiyotaka, Nishikawa Shin-ichi, Radtke Freddy, Osawa Masatake

Abstract excerpt

Recent studies have shown that Notch signaling plays an important role in epidermal development, but the underlying molecular mechanisms remain unclear. Here, by integrating loss- and gain-of-function studies of Notch receptors and Hes1, we describe molecular information about the role of Notch signaling in epidermal development. We show that Notch signaling determines spinous cell fate and induces terminal...

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Identifiers

PMID: 18410734
DOI: 10.1016/j.devcel.2008.01.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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