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Article

Pleiotropic Role of Notch Signaling in Human Skin Diseases.

International journal of molecular sciences - 13 Jun 2020

Gratton Rossella, Tricarico Paola Maura, Moltrasio Chiara, Lima Estevão de Oliveira Ana Sofia, Brandão Lucas, Marzano Angelo Valerio, Zupin Luisa, Crovella Sergio

Abstract excerpt

Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling route, might lead to both hyper- or hypo-activation of Notch signaling molecules and of target genes,...

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Identifiers

PMID: 32545758
DOI: 10.3390/ijms21124214
PMCID: PMC7353046

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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