Article
Analysis of the testis-determining gene SRY in patients with XY gonadal dysgenesis.
Hormone research - 1 Jan 1996
Tsutsumi O, Iida T, Nakahori Y, Taketani Y
Abstract excerpt
The sex-determining region of the Y chromosome (SRY) encodes a gene that has many of the properties expected to the testis-determining factor. XY gonadal dysgenesis is characterized by streak gonads in phenotypic females who lack the somatic abnormalities and short stature associated with Turner's syndrome. We have examined four patients with XY gonadal dysgenesis for the presence and absence of SRY and the DNA...
Topics
- Adolescent
- Adult
- DNA-Binding Proteins
- Female
- Gonadal Dysgenesis
- Humans
- Karyotyping
- Mutation
- Nuclear Proteins
- Phenotype
- Polymerase Chain Reaction
- Sex-Determining Region Y Protein
- Transcription Factors
- Y Chromosome