Article
Candidate genes in complete and partial XY sex reversal: mutation analysis of SRY, SRY-related genes and FTZ-F1.
Molecular and cellular endocrinology - 25 May 1998
Lim H N, Freestone S H, Romero D, Kwok C, Hughes I A, Hawkins J R
Abstract excerpt
The sexual phenotype is established in three steps: (1) the sex chromosome constitution; (2) the differentiation of the gonads; and (3) the response of the internal and external genitalia to the hormones produced by the differentiated gonads. Errors that occur at any of these stages can result in...
Topics
- Animals
- DNA-Binding Proteins
- Disorders of Sex Development
- Fushi Tarazu Transcription Factors
- Gene Dosage
- Gonadal Dysgenesis
- Homeodomain Proteins
- Humans
- Male
- Mice
- Mutation
- Nuclear Proteins
- Receptors, Cytoplasmic and Nuclear
- Sex Differentiation
- Sex-Determining Region Y Protein
- Steroidogenic Factor 1
- Testis
- Transcription Factors