Article
Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio.
BMC microbiology - 11 Apr 2008
Lintner Robert E, Mishra Pankaj K, Srivastava Poonam, Martinez-Vaz Betsy M, Khodursky Arkady B, Blumenthal Robert M
Abstract excerpt
BACKGROUND: Bacterial genome sequences are being determined rapidly, but few species are physiologically well characterized. Predicting regulation from genome sequences usually involves extrapolation from better-studied bacteria, using the hypothesis that a conserved regulator, conserved target gene, and predicted regulator-binding site in the target promoter imply conserved regulation between the two species....
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