Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito.

Journal of virology - 1 Jun 2008

Rojek Jillian M, Lee Andrew M, Nguyen NgocThao, Spiropoulou Christina F, Kunz Stefan

Abstract excerpt

The cellular proprotein convertase site 1 protease (S1P) has been implicated in the proteolytic processing of the glycoproteins (GPs) of Old World arenaviruses. Here we report that S1P is also involved in the processing of the GPs of the genetically more-distant South American hemorrhagic fever viruses Guanarito, Machupo, and Junin. Efficient cleavage of Guanarito virus GP, whose protease recognition sites...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CHO Cells
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoproteins

Share to Luciferases

Share to Proprotein Convertases

Share to Protein Precursors

Share to Serine Endopeptidases

Share to Vero Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18400865
DOI: 10.1128/JVI.02392-07
PMCID: PMC2395157

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Site 1 protease is required for proteolytic processing of the glycoproteins of the South American hemorrhagic fever viruses Junin, Machupo, and Guanarito.PMID 18400865Read ↗

Efficient reverse genetics generation of infectious junin viruses differing in glycoprotein processing.Semantic proximity Read ↗

Envelope Glycoprotein of ArenavirusesSemantic proximity Read ↗

Differential Recognition of Old World and New World Arenavirus Envelope Glycoproteins by Subtilisin Kexin Isozyme 1 (SKI-1)/Site 1 Protease (S1P)Semantic proximity Read ↗

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesisSemantic proximity Read ↗

A Host-Oriented Inhibitor of Junin Argentine Hemorrhagic Fever Virus EgressSemantic proximity Read ↗

Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.Semantic proximity Read ↗

Viral envelope glycoprotein processing by proprotein convertasesSemantic proximity Read ↗

In vitro proteolytic processing of the MD145 norovirus ORF1 nonstructural polyprotein yields stable precursors and products similar to those detected in calicivirus-infected cells.Semantic proximity Read ↗

The Glycoprotein of the Live-Attenuated Junin Virus Vaccine Strain Induces Endoplasmic Reticulum Stress and Forms Aggregates prior to Degradation in the Lysosome.Semantic proximity Read ↗

The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation.Semantic proximity Read ↗

Myristoylation of the Arenavirus Envelope Glycoprotein Stable Signal Peptide Is Critical for Membrane Fusion but Dispensable for Virion MorphogenesisSemantic proximity Read ↗

Processing of Nonstructural Protein 1a of Human AstrovirusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.