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Article

Processing of Nonstructural Protein 1a of Human Astrovirus

15 Feb 2002

Abstract excerpt

Astrovirus contains three open reading frames (ORF) on its genomic RNA, ORF1a, ORF1b, and ORF2. ORF1a encodes a 920-amino-acid (aa) nonstructural protein, nsP1a, which displays a 3C-like serine protease motif. Little is known about the processing of nsP1a or whether the protease it contains is active and involved in autocatalytic processing. Here we address both of these matters. Intact and N-terminally deleted...

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PMID: 11799197
DOI: 10.1128/jvi.76.4.2003-2008.2002

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