Article
Germline Variation at CDKN2A and Associations with Nevus Phenotypes among Members of Melanoma Families.
The Journal of investigative dermatology - 1 Dec 2017
Taylor Nicholas J, Mitra Nandita, Goldstein Alisa M, Tucker Margaret A, Avril Marie-Françoise, Azizi Esther, Bergman Wilma, Bishop D Timothy, Bressac-de Paillerets Brigitte, Bruno William, Calista Donato, Cannon-Albright Lisa A, Cuellar Francisco, Cust Anne E, Demenais Florence, Elder David E, Gerdes Anne-Marie, Ghiorzo Paola, Grazziotin Thais C, Hansson Johan, Harland Mark, Hayward Nicholas K, Hocevar Marko, Höiom Veronica, Ingvar Christian, Landi Maria Teresa, Landman Gilles, Larre-Borges Alejandra, Leachman Sancy A, Mann Graham J, Nagore Eduardo, Olsson Håkan, Palmer Jane M, Perić Barbara, Pjanova Dace, Pritchard Antonia, Puig Susana, van der Stoep Nienke, Wadt Karin A W, Whitaker Linda, Yang Xiaohong R, Newton Bishop Julia A, Gruis Nelleke A, Kanetsky Peter A
Abstract excerpt
Germline mutations in CDKN2A are frequently identified among melanoma kindreds and are associated with increased atypical nevus counts. However, a clear relationship between pathogenic CDKN2A mutation carriage and other nevus phenotypes including counts of common acquired nevi has not yet been established. Using data from GenoMEL, we investigated the relationships between CDKN2A mutation carriage and 2-mm, 5-mm,...
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