Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population.

Human immunology - 1 Mar 2008

Lombardi Maria Luisa, Terrazzano Giuseppe, Cosentini Elena, Gargiulo Lucia, Risitano Antonio, Camerlingo Rosa, Sica Michela, Aufiero Daniela, Poggi Alessandro, Pirozzi Giuseppe, Luzzatto Lucio, Rotoli Bruno, Notaro Rosario, Alfinito Fiorella, Ruggiero Giuseppina

Abstract excerpt

Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by the expansion of a PIG-A mutated hematopoietic stem cell. An immune-mediated origin has been suggested for this disease. Because HLA genes represent a susceptibility factor for autoimmunity, we investigated HLA genotype in 42 Italian PNH patients compared with 301 control subjects of the same ethnic origin. A significantly increased frequency of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Haplotypes
Share to Hemoglobinuria, Paroxysmal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A Antigens

Share to HLA-B Antigens

Share to HLA-C Antigens

Share to HLA-DQ Antigens

Share to HLA-DR Antigens

Source

Identifiers

PMID: 18396213
DOI: 10.1016/j.humimm.2008.02.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Paroxysmal nocturnal hemoglobinuria: significant association with specific HLA-A, -B, -C, and -DR alleles in an Italian population.PMID 18396213Read ↗

The patterns of MHC association in aplastic and non-aplastic paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Killer immunoglobulin-like receptors (KIR) and their HLA-ligands in Italian paroxysmal nocturnal haemoglobinuria (PNH) patients.Semantic proximity Read ↗

Potential link between MHC-self-peptide presentation and hematopoiesis; the analysis of HLA-DR expression in CD34-positive cells and self-peptide presentation repertoires of MHC molecules associated with paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

[Paroxysmal nocturnal hemoglobinuria].Semantic proximity Read ↗

Nationwide real-world cohort of paroxysmal nocturnal hemoglobinuria in ChileSemantic proximity Read ↗

Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Immune pathogenesis of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Clinical features and prognostic factors of Asian patients with paroxysmal nocturnal hemoglobinuria: results from a single center in China.Semantic proximity Read ↗

A systematic analysis of bone marrow cells by flow cytometry defines a specific phenotypic profile beyond GPI deficiency in paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria in children.Semantic proximity Read ↗

Molecular genetics of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.