Article
Genes in congenital heart disease: atrioventricular valve formation.
Basic research in cardiology - 1 May 2008
Joziasse Irene C, van de Smagt Jasper J, Smith Kelly, Bakkers Jeroen, Sieswerda Gert-Jan, Mulder Barbara J M, Doevendans Peter A
Abstract excerpt
Through the use of animal studies, many candidate genes (mainly encoding transcriptional factors and receptors) have been implicated in the development of congenital heart disease. Thus far, only a minority of these genes have been shown to carry mutations associated with congenital disease in humans, e.g., GATA 4, TBX-5, NOTCH1 and NKX2-5. Mutations in these genes can cause a variety of cardiac defects even...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.