Hairy cell leukemia: a specific 17-gene expression signature points to new targets for therapy

Abstract excerpt

BACKGROUND: Hairy cell leukemia (HCL) is a rare chronic B cell malignancy, characterized by infiltration of bone marrow, blood and spleen by typical "hairy cells" that bear the BRAFV600E mutation. However, in addition to the intrinsic activation of the MAP kinase pathway as a consequence of the BRAFV600E mutation, the potential participation of other signaling pathways to the pathophysiology of the disease...

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• Chronic Lymphocytic Leukemia Research
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• T-cell and Retrovirus Studies