Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapy

30 Jul 2019

Abstract excerpt

To investigate the possibility that HIV-1 replication in lymph nodes sustains the reservoir during ART, we looked for evidence of viral replication in 5 donors after up to 13 years of viral suppression. We characterized proviral populations in lymph nodes and peripheral blood before and during ART, evaluated the levels of viral RNA expression in single lymph node and blood cells, and characterized the proviral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV/AIDS Research and Interventions
Share to HIV Research and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31361603
DOI: 10.1172/jci126714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 in lymph nodes is maintained by cellular proliferation during antiretroviral therapyPMID 31361603Read ↗

Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral TherapySemantic proximity Read ↗

Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ARTSemantic proximity Read ↗

HIV persistence in lymph nodesSemantic proximity Read ↗

Single Cell Analysis of Lymph Node Tissue from HIV-1 Infected Patients Reveals that the Majority of CD4+ T-cells Contain One HIV-1 DNA MoleculeSemantic proximity Read ↗

Extensive characterization of HIV-1 reservoirs reveals links to plasma viremia before and during analytical treatment interruptionSemantic proximity Read ↗

Similar Frequency and Inducibility of Intact Human Immunodeficiency Virus-1 Proviruses in Blood and Lymph NodesSemantic proximity Read ↗

Longitudinal Genetic Characterization Reveals That Cell Proliferation Maintains a Persistent HIV Type 1 DNA Pool During Effective HIV TherapySemantic proximity Read ↗

Assessment of HIV-1 integration in tissues and subsets across infection stagesSemantic proximity Read ↗

Proliferation of cells with HIV integrated into cancer genes contributes to persistent infectionSemantic proximity Read ↗

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors.Semantic proximity Read ↗

HIV-1 Actively Replicates in Naive CD4+ T Cells Residing within Human Lymphoid TissuesSemantic proximity Read ↗

Why the HIV Reservoir Never Runs Dry: Clonal Expansion and the Characteristics of HIV-Infected Cells Challenge Strategies to Cure and Control HIV InfectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.