Article
Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer.
Biochimica et biophysica acta - 1 Mar 2010
Eck Michael J, Yun Cai-Hong
Abstract excerpt
EGFR and other ErbB-family tyrosine kinases are overexpressed in many human tumors, and their aberrant expression and mutational activation is associated with the development, progression and aggressiveness of a number of malignancies. Thus the EGFR kinase has long been recognized as a potential...
Topics
- Animals
- Catalytic Domain
- Drug Resistance, Neoplasm
- Enzyme Activation
- ErbB Receptors
- Erlotinib Hydrochloride
- Gefitinib
- Humans
- Lung Neoplasms
- Mutation
- Protein Kinase Inhibitors
- Protein Structure, Tertiary
- Quinazolines
- Small Cell Lung Carcinoma
- Structure-Activity Relationship