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Article

Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers

29 Mar 2008

Abstract excerpt

Epidermal morphology of chronic wounds differs from that of normal epidermis. Biopsies of non-healing edges obtained from patients with venous ulcers show thick and hyperproliferative epidermis with mitosis present in suprabasal layers. This epidermis is also hyper-keratotic and parakeratotic. This suggests incomplete activation and differentiation of keratinocytes. To identify molecular changes that lead to...

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PMID: 18373736
DOI: 10.1111/j.1582-4934.2008.00321.x

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