Assessment of Phenotype, Oxidative Stress and Biomacromolecule Oxidation in Human Chronic Skin Wound Epidermis in Active Debridement Tissue Versus Endstage Wounds.

doi:10.1111/wrr.70196

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Article

Assessment of Phenotype, Oxidative Stress and Biomacromolecule Oxidation in Human Chronic Skin Wound Epidermis in Active Debridement Tissue Versus Endstage Wounds.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society - 1 Jan 2026

Tinney Dylan, Carmichael Justin, Chawla Punkuj, Keast David, Hamilton Douglas W

Abstract excerpt

Impairment of cutaneous healing occurs in association with numerous comorbidities including diabetes, vascular insufficiency and immobility. Standard management of chronic wounds includes removal of necrotic tissue and infection management, but no biomarkers are used to guide appropriate debridement distance. We hypothesized that by understanding the spatial distribution of proteins associated with keratinocyte...

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Topics

Humans
Filaggrin Proteins
Oxidative Stress
Wound Healing
Epidermis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Debridement

Chronic Disease

Keratinocytes

Phenotype

Biomarkers

Male

Amputation, Surgical

Wounds and Injuries

Oxidation-Reduction

Keratins

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 42684004
DOI: 10.1111/wrr.70196
PMCID: PMC13536918

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