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Article

The PDCD4/miR-21 pathway in medullary thyroid carcinoma.

Human pathology - 1 Jan 2015

Pennelli Gianmaria, Galuppini Francesca, Barollo Susi, Cavedon Elisabetta, Bertazza Loris, Fassan Matteo, Guzzardo Vincenza, Pelizzo Maria Rosa, Rugge Massimo, Mian Caterina

Abstract excerpt

Programmed cell death 4 (PDCD4) is a tumor suppressor gene involved in tumorogenesis. MicroRNA-21 (miR-21) specifically targets PDCD4, and recent studies suggest that PDCD4 is also regulated by Akt (antiapoptotic regulator within phosphatidylinositol 3-kinase). Medullary thyroid carcinoma (MTC) i...

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Source

Identifiers

PMID: 25316501
DOI: 10.1016/j.humpath.2014.09.006

Genes

PDCD4
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25316501-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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