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Article

The pathological interaction between diabetes and presymptomatic Alzheimer's disease.

Neurobiology of aging - 1 Dec 2009

Burdo Joseph R, Chen Qi, Calcutt Nigel A, Schubert David

Abstract excerpt

Since diabetes is a risk factor for Alzheimer's disease (AD), we asked if there is a functional interaction between high glucose and elevated beta amyloid peptide (Abeta) in cultured brain microvascular endothelial cells and presymptomatic AD transgenic mice. When cultured brain microvascular endothelial cells are exposed to both high glucose and low levels of Abeta, there is a synergistic interaction to cause an...

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Identifiers

PMID: 18372080
DOI: 10.1016/j.neurobiolaging.2008.02.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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