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Article

West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection.

Journal of virology - 1 Feb 2006

Davis Carl W, Nguyen Hai-Yen, Hanna Sheri L, Sánchez Melissa D, Doms Robert W, Pierson Theodore C

Abstract excerpt

The C-type lectins DC-SIGN and DC-SIGNR bind mannose-rich glycans with high affinity. In vitro, cells expressing these attachment factors efficiently capture, and are infected by, a diverse array of appropriately glycosylated pathogens, including dengue virus. In this study, we investigated whether these lectins could enhance cellular infection by West Nile virus (WNV), a mosquito-borne flavivirus related to...

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Identifiers

PMID: 16415006
DOI: 10.1128/JVI.80.3.1290-1301.2006
PMCID: PMC1346927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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