The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.

doi:10.1371/journal.ppat.1000034

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Article

The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis.

PLoS pathogens - 28 Mar 2008

Caws Maxine, Thwaites Guy, Dunstan Sarah, Hawn Thomas R, Lan Nguyen Thi Ngoc, Thuong Nguyen Thuy Thuong, Stepniewska Kasia, Huyen Mai Nguyet Thu, Bang Nguyen Duc, Loc Tran Huu, Gagneux Sebastien, van Soolingen Dick, Kremer Kristin, van der Sande Marianne, Small Peter, Anh Phan Thi Hoang, Chinh Nguyen Tran, Quy Hoang Thi, Duyen Nguyen Thi Hong, Tho Dau Quang, Hieu Nguyen T, Torok Estee, Hien Tran Tinh, Dung Nguyen Huy, Nhu Nguyen Thi Quynh, Duy Phan Minh, van Vinh Chau Nguyen, Farrar Jeremy

Abstract excerpt

The factors that govern the development of tuberculosis disease are incompletely understood. We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are more capable of causing disseminated disease than others and may be associated with polymorphisms in host genes responsible for the innate immune response to infection. We compared the host and bacterial genotype in 187 Vietnamese adults...

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PMID: 18369480
DOI: 10.1371/journal.ppat.1000034
PMCID: PMC2268004

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