Host genetics and tuberculosis: Theory of genetic polymorphism and tuberculosis

Abstract excerpt

BACKGROUND AND OBJECTIVE: Tuberculosis (TB), the leading cause of morbidity and mortality by a single infectious agent, Mycobacterium tuberculosis, is still a major health problem in the world. To date, many studies have shown evidence of association between host genetic polymorphisms and TB susceptibility, including chemokine (C-C motif) ligand 2 (CCL-2)/monocyte chemoattractant protein1 (MCP-1), natural...

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