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Article

Aedes aegyptiuses RNA interference in defense against Sindbis virus infection

17 Mar 2008

Abstract excerpt

BACKGROUND: RNA interference (RNAi) is an important anti-viral defense mechanism. The Aedes aegypti genome encodes RNAi component orthologs, however, most populations of this mosquito are readily infected by, and subsequently transmit flaviviruses and alphaviruses. The goal of this study was to use Ae. aegypti as a model system to determine how the mosquito's anti-viral RNAi pathway interacts with recombinant...

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PMID: 18366655
DOI: 10.1186/1471-2180-8-47

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