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Suppression of RNA interference increases alphavirus replication and virus-associated mortality in Aedes aegypti mosquitoes

5 Mar 2009

Abstract excerpt

BACKGROUND: Arthropod-borne viruses (arboviruses) can persistently infect and cause limited damage to mosquito vectors. RNA interference (RNAi) is a mosquito antiviral response important in restricting RNA virus replication and has been shown to be active against some arboviruses. The goal of this study was to use a recombinant Sindbis virus (SINV; family Togaviridae; genus Alphavirus) that expresses B2 protein...

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PMID: 19265532
DOI: 10.1186/1471-2180-9-49

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