The effects of long term monolayer culture on the proteoglycan phenotype of a clonal population of mature human malignant chondrocytes.

doi:10.3109/03008209109152446

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Article

The effects of long term monolayer culture on the proteoglycan phenotype of a clonal population of mature human malignant chondrocytes.

Connective tissue research - 1 Jan 1991

Block J A, Inerot S E, Gitelis S, Kimura J H

Abstract excerpt

Articular cartilage chondrocytes maintain biosynthetic heterogeneity in cell culture, but undergo irreversible dedifferentiation of their proteoglycan phenotype, as defined by keratan sulfate content. A recently described cell line of malignant human chondrocytes, 105KC, was the first to maintain...

Topics

Chondroitin Sulfates
Chondrosarcoma
Clone Cells
Extracellular Matrix
Glycosaminoglycans
Humans
Keratan Sulfate
Morphogenesis
Phenotype
Proteoglycans
Tumor Cells, Cultured

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