Article
Strain differences in mice highlight the role of DNA damage in neoplasia induced by low dietary folate.
The Journal of nutrition - 1 Apr 2008
Knock Erin, Deng Liyuan, Wu Qing, Lawrance Andrea K, Wang Xiao-ling, Rozen Rima
Abstract excerpt
In earlier work, we showed that low dietary folate induced intestinal tumors in BALB/c mice. In this study, our goal was to examine the effect of the same diets on a strain that is more resistant to tumorigenesis (C57Bl/6). We also questioned whether supplementation of the folate-deficient diet (FD) with betaine, an alternate methyl donor, would influence tumor formation. C57Bl/6 mice were fed the same diets...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.