Article
Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease.
The Journal of pathology - 1 Jun 2008
Keita A V, Salim S Y, Jiang T, Yang P-C, Franzén L, Söderkvist P, Magnusson K-E, Söderholm J D
Abstract excerpt
In Crohn's disease (CD), inflammation is driven by luminal commensal micro-organisms; however, mechanisms of early phases of inflammation need further clarification. The earliest observable lesions of recurrent CD are microscopic erosions at the specialized follicle-associated epithelium (FAE), which lines the Peyer's patches. Therefore, our aim was to investigate the mucosal barrier to non-pathogenic bacteria in...
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