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Article

The path to Crohnʼs disease: Is mucosal pathology a secondary event?

19 Nov 2009

Abstract excerpt

Current models of Crohn's disease (CD) invoke an initial disturbance of the epithelial interface between the gut mucosa and intestinal microbiota. This "outside-in" paradigm, mirroring the pathophysiology of acute gastroenteritis, suggests that mucosal damage by luminal bacteria is an early, initiating factor in the etiopathogenesis of disease. However, a number of features of CD argue against a primary mucosal...

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PMID: 19924803
DOI: 10.1002/ibd.21171

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