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Article

Analysis of SOX2 expression in developing human testis and germ cell neoplasia

29 Oct 2009

Abstract excerpt

The transcriptional regulators of pluripotency, POU5F1 (OCT4), NANOG and SOX2, are highly expressed in embryonal carcinoma (EC). In contrast to OCT4 and NANOG, SOX2 has not been demonstrated in the early human germ cell lineage or carcinoma in situ (CIS), the precursor for testicular germ cell tumours (TGCTs). Here, we have analysed SOX2 expression in CIS and overt TGCTs, as well as normal second and third...

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PMID: 19876845
DOI: 10.1387/ijdb.082668ss

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