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Article

Axl promotes cell invasion by inducing MMP-9 activity through activation of NF-kappaB and Brg-1.

Oncogene - 3 Jul 2008

Tai K-Y, Shieh Y-S, Lee C-S, Shiah S-G, Wu C-W

Abstract excerpt

Activity of the Axl receptor tyrosine kinase is positively correlated with tumor metastasis; however, its detailed role in the mechanism of tumor invasion is still not completely understood. Here, we show that Axl enhances the expression of matrix metalloproteinase 9 (MMP-9), required for Axl-mediated invasion both in vitro and in vivo. We found that the highly selective MEK1/2 inhibitors U0126 and PD98059, and...

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Source

Identifiers

PMID: 18345028
DOI: 10.1038/onc.2008.57

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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