Article
Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors.
Oncogene - 10 Jul 2008
Wang I-C, Meliton L, Tretiakova M, Costa R H, Kalinichenko V V, Kalin T V
Abstract excerpt
The forkhead box m1 (Foxm1 or Foxm1b) protein (previously called HFH-11B, Trident, Win or MPP2) is abundantly expressed in human non-small cell lung cancers where it transcriptionally induces expression of genes essential for proliferation of tumor cells. In this study, we used Rosa26-Foxm1 transgenic mice, in which the Rosa26 promoter drives ubiquitous expression of Foxm1 transgene, to identify new signaling...
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