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Article

HLA-A alleles including HLA-A29 affect the composition of the gut microbiome: a potential clue to the pathogenesis of birdshot retinochoroidopathy.

Scientific reports - 19 Oct 2020

Sternes Peter R, Martin Tammy M, Paley Michael, Diamond Sarah, Asquith Mark J, Brown Matthew A, Rosenbaum James T

Abstract excerpt

Birdshot retinochoroidopathy occurs exclusively in individuals who are HLA-A29 positive. The mechanism to account for this association is unknown. The gut microbiome has been causally implicated in many immune-mediated diseases. We hypothesized that HLA-A29 would affect the composition of the gut microbiome, leading to a dysbiosis and immune-mediated eye disease. Fecal and intestinal biopsy samples were obtained...

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Identifiers

PMID: 33077849
DOI: 10.1038/s41598-020-74751-0
PMCID: PMC7572371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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